Each monograph contains stability data, administration guidelines, and methods of preparation. Sandostatin octreotide acetate dose, indications, adverse. Compared with the somatostatin, octreotide is highly resistant to enzymatic degradation and has a prolonged. Atropine sulfate, morphine sulfate, morphine hydrochloride, octreotide acetate, omeprazole sodium, pralidoxime chloride, and tramadol hydrochloride.
Immediaterelease injection may be diluted in 50200 ml of 0. All drug compatibility combinations derived from these guidelines should be checked and. This medication works by blocking the production of these. Apr 10, 2011 a continuous iv infusion of octreotide at 1. Similar to somatostatin, this agent also suppresses the luteinizing hormone. Thus, somatostatin or octreotide can be used as adjunctive therapy before endoscopy, or when endoscopy. Octreotide has been recommended for the management of hypoglycemia induced by sulfonylureas. Octreotide bcca cancer drug manual page 6 of 9 octreotide developed. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication. Antidiarrheal pregnancy risk category b action suppresses secretion of serotonin, serotonin metabolites, and gastrohepatic peptides, increasing fluid and electrolyte absorption from gi tract. Its pharmacodynamic properties are similar to those of somatostatin, with a wide spectrum of inhibitory effects on anterior pituitary function, pancreas and gut endocrine secretions, and gastrointestinal functions. The nola nets group uses thisothers use lesscant speak to their results but even with these higher than others type dosing we have had 2 carcinoid crisis out of about 300 or visits two hours before surgery give 500 micrograms of octreotide acetate iv push. Octreotide acetate is the acetate salt of a synthetic longacting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin.
Octreotide acetate sandostatin, sandostatin lar is an injectable drug prescribed to treat certain people with acromegaly and to treat severe diarrhea and flushing caused by some hormonesecreting cancers. Sandostatin, sandostatin lar octreotide dosing, indications. Octreotide acetate is commercially available as an immediaterelease shortacting injection for subq or iv administration and as a longacting extendedrelease suspension for im administration. Octreotide is a manmade protein that is similar to a hormone in the body called somatostatin. Octreotide acetate injection is stable in sterile isotonic saline solutions or sterile solutions of dextrose 5% in water for 24 hours. Clinical pharmacokinetics of octreotide springerlink. Octreotide therapy may be used to reduce fistula output in doses of 100 to 250 mcg. By deep intramuscular injection using depot injection.
Sandostatin, sandostatin lar depot octreotide injection. A legend at the bottom of the page lists all compatibility types, and hovering your mouse over the icon will open a popup with the full compatibility description. Due to the apparent low risktobenefit profile, a much higher dose is sometimes used in urgent situations. Intravenous injection introduced directly into a vein or a freely flowing iv line. Direct iv administration is generally reserved for emergencies e. Octreotide 100 micrograms1ml solution for injection.
The octreotide acts similar to the hormone somatostatin. Apr 23, 2019 what is octreotide sandostatin, sandostatin lar depot. The half life of octreotide in the blood is about 90120 minutes the halflife is the amount of time that it takes for your body to clear one half of the drug from the blood after about 6 hours the levels of octreotide have fallen to levels that are not commonly associated with biologic activity. In adults, sc doses of octreotide at 100, 250, and 500. Oct 10, 2012 piggyback is sort of a slang term with no single definition.
Among somatostatin analogues, octreotide is the most extensively studied. Ecg and blood pressure monitoring required for iv doses. Octreotide brand name sandostatin, among others is an octapeptide that mimics natural somatostatin pharmacologically, though it is a more potent inhibitor of growth hormone, glucagon, and insulin than the natural hormone. Octreotide is used to treat severe watery diarrhea and sudden reddening of the face and neck caused by certain types of tumors e. Megadose intravenous octreotide for the treatment of. The symptoms occur when these tumors make too much of certain natural substances hormones. Octreotide is available in an injectable form to be given directly into a vein iv by a healthcare professional. If you have a lasix drip going at 10cchr and you ysite into the upper not the secondary ysite and there is 10mls. Clinical andor biochemical response may diminish to some extent during prolonged therapy. The drug is also prescribed for acromegaly a condition in. Sandostatin octreotide acetate immediaterelease injection is available for treatment initiation and symptom flareups. Octreotide dbl also contains glacial acetic acid, sodium acetate trihydrate and sodium chloride. Octreotide is a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin.
For solution and drug compatibility information, see compatibility under stability. It was first synthesized in 1979, by the chemist wilfried bauer. Most women were exposed to octreotide during the first trimester of pregnancy at doses ranging from 1001200 microgramsday of octreotide s. A depot formulation of octreotide 1030 mg, given every 4 weeks is available sandotatin lar. Sep 12, 2019 octreotide acetate injection is stable in sterile isotonic saline solutions or sterile solutions of dextrose 5% in water for 24 hours. Webmd provides common contraindications for octreotide acetate injection. Octreotide is also used to reduce flushing episodes and watery diarrhea. Ns or d5w preferred diluent for acetaminophen overdose acyclovir. Intravenous admixtures preparation and infusion guidelines.
Octreotide is a synthetic peptide analog of somatostatin with the same pharmacologic effects. Theres an excellent book i recommend you read to help improve your. Patients receiving iv pantoprazole often require concomitant iv drugs and solutions. Intravenous compatibility chart drug information for the. The nola nets group uses thisothers use lesscant speak to their results but even with these higher than others type dosing we have had 2 carcinoid crisis out of about 300 or visits two hours before surgery give. Piggyback is sort of a slang term with no single definition. Compatibility is denoted by an icon and simple description.
It may be diluted in volumes of 50 to 200 ml and infused intravenously over 15 to 30 minutes or administered by iv push over 3 minutes. It is a clear liquid that is usually injected under the skin daily injection or. The essential information you need to safely administer more than 400 intravenous drugs. In addition to updating drug interactions, precautions, alerts, and patient teaching. However, with sandostatin octreotide acetate lar depot 40 mg once a month, the incidence of new cholelithiasis in this pediatric population 33% was higher than that seen in other adults indications such as acromegaly 22% or malignant carcinoid syndrome 24%, where sandostatin octreotide acetate lar depot was 10 to 30 mg once a month. The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Octreotide fda prescribing information, side effects and uses. Octreotide acetate injection is available as sterile 1 ml singledose vials in 3 strengths, each ml containing 50 mcg, 100 mcg, or 500 mcg of octreotide acetate, usp as the active and the following inactive ingredients.
Octreotide octreotide acetate injection, solution dailymed. Octreotide acetate pharmacokinetics absorption bioavailability. Iv compatibility results are organized onto separate tabs, so that you can quickly access the route or method in which you are interested. What you need to consider with ysiting is how it will affect both fluids. Detailed listing of the iv drug compatibility and stability updates applied to the king guide to parenteral admixtures over the last 12 years. Do not confuse with sandostatin lar which is a depot octreotide preparation that can only be given im.
This book is distributed under the terms of the creative commons. Octreotide administration may be through a subcutaneous or intravenous route. Octreotide belongs to a class of drugs called octapeptides, which work by decreasing the amounts of certain natural substances. Initially 20 mg every 4 weeks for 3 months then adjusted according to response, increased if necessary up to 30 mg every 4 weeks, to be administered into the gluteal muscle, for acromegaly, start depot 1 day after the last dose of subcutaneous octreotide, for neuroendocrine tumours, continue subcutaneous octreotide for 2 weeks. Somatostatin is found within the pancreas, recommendations level 1. Octreotide are amino acid monomer which is attached to amide group. The risk also appeared to be reduced with octreotide, although there were fewer studies.
Syringe driver drug compatibilities practice guidelines. Product monograph prsandostatin octreotide acetate injection 50 g ml, 100 g ml, 200 g ml, 500 g ml prsandostatin lar octreotide as acetate for injectable suspension 10, 20 or 30 mg octreotide as acetate per vial synthetic octapeptide analogue of somatostatin novartis pharmaceuticals canada inc. Its primary advantages over somatostatin are a longer halflife in the circulation, a higher potency, and good bioavailability after subcutaneous administration. Compared with the somatostatin, octreotide is highly resistant to. Adult critical care iv medication infusion sheet lidocaine 4 mgml mg250ml d5w premix ns 14 mgmin 5 mgmin 16 mgml4 c or p lorazepam 0. Initially 20 mg every 4 weeks for 3 months then adjusted according to response, increased if necessary up to 30 mg every 4 weeks, to be administered into the gluteal muscle, for acromegaly, start depot 1 day after the last dose of subcutaneous octreotide, for neuroendocrine tumours, continue subcutaneous octreotide for 2. The description of the first study cited in the trissels compatibility table states that octreotide 5 mcgml in d5w is incompatible in pantoprazole 0. Therefore this book should be used as guidance only.
Find out what health conditions may be a health risk when taken with octreotide acetate injection. For compatibility data in water for injection, see charts a4. It was approved for use in the united states in 1988. Intravenous compatibility chart free html5 flip book. A skin reaction at the infusion site is most commonly found with cyclizine, ketamine. Octreotide market global industry analysis, size and. Octreotide fda prescribing information, side effects and. This reference contains standard dilutions including iv admixture drug concentration, infusion volumes, and infusion rates. Sandostatin lar depot octreotide acetate for injectable suspension is available in 10 mg, 20 mg, and 30 mg for up or down dose titration. Octreotide, a somatostatin analogue, is administered as a bolus dose of 100500. Sandostatin lar depot octreotide acetate for injectable. Octreotide comes as an immediaterelease injection to be injected subcutaneously under the skin or intravenously into a vein and as a longacting injection to be injected into the muscles of the buttocks by a doctor or nurse. Physical compatibility of pantoprazole with selected.
Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropin. Save money on your sandostatin injection prescription by switching to tevas fdaapproved generic version, octreotide acetate injection. Therapeutic applications of octreotide in pediatric patients. Octreotide 100 to 200 mcg subcutaneously 3 times daily in combination with midodrine range. Regardless of how you get there when searching for iv compatibility of. Following subq injection, immediaterelease formulation is rapidly and completely absorbed. Octreotide acetate definition of octreotide acetate by. More details and 3drug compatibility data can be found on. Octreotide lowers many substances in the body such as insulin and glucagon involved in regulating blood sugar, growth hormone, and chemicals that affect digestion octreotide is used to treat acromegaly. Octreotide basically lowers the variety of hormone such as insulin, glucagon, growth hormone and others, octreotide reduces chemical messengers such as gastrin, vasoactive intestinal peptide that cause disease symptoms. The primary fdaapproved indications of octreotide, seen by clinical. Octreotide definition of octreotide by medical dictionary. Octreotide has been associated with alterations in nutrient absorption, so it may have an effect on absorption of orally administered drugs limited published data indicate that somatostatin analogs might decrease the metabolic clearance of compounds known to be metabolized by cytochrome p450 enzymes, which may be due to the suppression of. Iv injection suitable for shortacting formulations only in the treatment of oesophageal varices.
Dilute each 1ml octreotide with 1 9ml sodium chloride 0. A handbook for nurses and health professionals has been a trusted resource for comprehensive drug coverage, unparalleled accuracy, and an intuitive quickaccess format. The drug is also prescribed for acromegaly a condition in which the body produces too much growth. The related drug information index provides comprehensive access to all drug information related to a specific drug types of content include full prescribing information, drug summaries, full prescribing information continuing medication education full pi cme, medication guides, risk evaluation and mitigation strategies rems summaries, rems continuing medication education rems cme, and.
Intravenous iv preparation and infusion guidelines globalrph. Octreotide lar up to 30 mg monthly responsiveness appeared similar to that observed for the subcutaneous preparation in 7 patients. Octreotide acetate is stable in sterile isotonic saline solutions or sterile solutions of dextrose 5% in water for 24 hours. To complete a visual compatibility study of iv pantoprazole with 17 other iv. Octreotide is a synthetic longacting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide sandostatin side effects, dosage, interactions. Physical compatibility of pantoprazole with selected medications. Octreotide immediaterelease injection is usually injected 2 to 4 times a day.
Trissel, fashp, 2010, american society of healthsystem pharmacists. Trissels 2 clinical pharmaceutics database parenteral compatibility greenwood village, colorado. This medication is usually given by injection under the skin, usually 2 to 3 times a day or as directed by your doctor. Octreotide is a drug used to treat diarrhea and skin flushing caused by certain types of cancer. Side effects, drug interactions, warnings, precautions, dosing, storage, pregnancy, and breastfeeding safety information is provided. These substances may be made in excessive amounts by the body because of certain conditions like tumors. Home explore intravenous compatibility chart drug information for the. Octreotide is an analog of somatostatin which can reduce gastrointestinal, biliary, and pancreas secretions, as well as decrease gastrointestinal motility 1. Ysite versus piggyback patient medications allnurses. Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropinreleasing hormone, decreases. In a randomized controlled trial of 50 ml of 50% dextrose intravenously, oral carbohydrate with 50 ml of 50% dextrose and oral carbohydrate plus subcutaneous octreotide.
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